The current review focus on role of Poly-hydroxybutyrate (PHB) in pharmaceutical formulation. PHB is a biodegradable thermoplastic which have considerable pharmaceutical importance. PHB biopolymer is effective tool for controlling the drug release profile of formulations. It is an energy-storage polymer both natural and recombinant microorganisms have been used for PHB production. The structure, properties and regulation of synthesis and degradation of PHB are varying according to source of synthesis. It has been widely used in biomedical applications because of their known biocompatibility and biodegradability. Drug delivery plays an optimistic role in the development of pharmaceutical Formulation for the health care of population. The drug release duration is needs to be extended over days up to several months. Progress in formulation is achieved by merging of drugs substances into polymeric components to control release of drug from drug polymer complex at a reproducible and predefined rate for an extended time period. This polymeric biomaterial is preferred candidates for developing controlled/sustained release drug delivery vehicles, therapeutic devices such as temporary prostheses. The known reason to use the PHB in Pharmaceutical and biomedical application because of their bio-acceptance and patient compliance.
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